Bugs that Keep You Healthy: Microbes and Your Immune Function

  1. Do you seem to get sick with every single cold your kids bring home? Do you think your immune system is not working the way it should be? You try to take vitamin C or wash your hands more often, but nothing seems to work. If you are struggling with always getting sick, the problem could be your digestive system.

    Your Gut and Your Health

    Up to 80% of your immune activity takes place in your gut and the microbiome is at the center of that activity. The gut microbiome is the collection of billions of bacteria that live inside the digestive tract. We used to think these microbes were just along for the ride. But new research is revealing that there is a significant connection between gut health and overall health, especially in terms of immune function. (1,2,3)

    Beneficial gut bacteria directly influence the immune system and how often you get sick in a few different ways: (4)

    • Decrease inflammation by controlling the release of inflammatory compounds
    • Increase activity of white blood cells, specifically macrophages and natural killer cells
    • Maintain gut integrity to prevent harmful pathogens from passing through
    • Help break down essential nutrients needed for immune function
    • Compete for nutrition and space with harmful bacteria
    Doctors Pick Probiotics

    Your diet, stress levels, previous illnesses, and antibiotic use can all throw off the balance of the gut microbiome, negatively impacting your immune function. An imbalance of bacteria in the gut might be the reason why you are sick all the time. Luckily, you can restore the health of your gut microbes and improve your immune health.

    Restoring Immune Function with Probiotics

    Probiotics are bacteria found in supplements and certain foods that can help re-balance the microbiome and boost immune function.

    A 2014 study evaluated the impact of taking a probiotic supplement on the immune function of elite rugby athletes. Athletes are prone to respiratory illness due to the regular physical stress they must endure, making them great subjects for studies on improving immune function. In this particular study, athletes were given a probiotic supplement or a placebo for 4 weeks.

    Of those who received the probiotic 16 out of 30 got sick during the study period, whereas 24 out of 30 in the placebo group got sick. Of the athletes who received the probiotic and got sick, the illness was 2 days shorter. (5)

    Probiotics may help reduce the risk of digestive illnesses as well. A 2017 meta-analysis of 27 studies found that probiotic supplements reduced the risk of Clostridium Difficile infection by 60%, even when researchers controlled for variations in dosage, age, and illness. The effect of the probiotic was even more pronounced for participants who had a greater risk of developing the infection. (6)

    Immune Boosting Probiotic Strains

    The best way to support your immune system is to regularly eat probiotic-rich foods or take a probiotic supplement.

    Fermented foods, like yogurt or sauerkraut, can be fairly high in probiotics and should be a regular part of your diet. But, the probiotic strains (varieties) in them can be limited. And, there is no way to know exactly which bacterial strains are in these foods, unless specifically listed on the label. Kombucha is a fermented drink source of probiotics. However, they have relatively low amounts of probiotics of only a few varieties, and often come packed with sugar and other additives that offset any probiotic benefit. Although fermented foods are a great addition to your diet, eating them doesn’t allow you to specifically target immune health.

    Doctors Pick Probiotics
    Doctors Pick Probiotics

    A probiotic supplement gives you more control over the bacterial species you are consuming. There are hundreds of probiotic strains found in supplements, but only a few specific ones have immune-stimulating properties. These include: (7)

    •         Lactobacillus plantarum
    •         Lactobacillus casei
    •         Lactobacillus rhamnosus
    •         Lactobacillus acidophilus
    •         Streptococcus thermophiles
    •         Bifidobacterium infantis

    *All of these strains are found in our Doctor’s Pick 50 Billion CFU probiotic and our soon to be introduced FEM-PRO 59.5 Women’s Daily Probiotic. 

    Taking probiotics with these specific strains can help rebalance your gut microbiome and restore healthy immune function. The better balance and diversity of bacteria in your gut, the stronger your immune system will become. Probiotics are one way to give your immune system a boost from the inside out so your body is able to defend itself against any illness your kids bring home. 

    References

    1. Tilg H, Moschen AR. Food, immunity, and the microbiome. Gastroenterology. 2015;148(6):1107-1119. https://www.ncbi.nlm.nih.gov/pubmed/25575570
    2. Faria AMC, Gomes-Santos AC, Gonçalves JL, et al. Food components and the immune system: from tonic agents to allergens. Front Immunol. 2013;4:102. https://www.frontiersin.org/articles/10.3389/fimmu.2013.00102/full
    3. Purchiaroni F, Tortora A, Gabrielli M, et al. The role of intestinal microbiota and the immune system. Eur Rev Med Pharmacol Sci. 2013;17(3):323-333. https://www.ncbi.nlm.nih.gov/pubmed/23426535
    4. Fata G, Weber P, Mohajeri MH. Probiotics and the Gut Immune System: Indirect Regulation. Probiotics Antimicrob Proteins. 2018;10(1):11-21. https://www.ncbi.nlm.nih.gov/pubmed/28861741
    5. Haywood BA, Black KE, Baker D, McGarvey J, Healey P, Brown RC. Probiotic supplementation reduces the duration and incidence of infections but not severity in elite rugby union players. J Sci Med Sport. 2014;17(4):356-360. https://www.sciencedirect.com/science/article/abs/pii/S1440244013001904
    6. Goldenberg JZ, Yap C, Lytvyn L, et al. Probiotics for the prevention of Clostridium difficile‐associated diarrhea in adults and children. Cochrane Database Syst Rev. 2017;(12). https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD006095.pub4/abstract
    7. Yan F, Polk DB. Probiotics and immune health. Curr Opin Gastroenterol. 2011;27(6):496-501. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006993/
 

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THE 15 TOP CLINICALLY STUDIED PROBIOTIC STRAINS IN DOCTORS PICK BROAD PRO

(References at bottom of page: Most studies cited here were conducted on humans; only a relatively few listed involve lab animals.)
Doctors Pick BROAD PRO brings the best science has to offer

References:

 

Lactobacillus Acidophilus
  1. https://www.cancer.gov/publications/dictionaries/cancer-drug/def/probiotic-acidophilus
  2. https://www.ncbi.nlm.nih.gov/pubmed/8551535
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847857/
  4. https://www.ncbi.nlm.nih.gov/pubmed/23747589
  5. https://www.ncbi.nlm.nih.gov/pubmed/10067658
  6. https://www.journalofdairyscience.org/article/S0022-0302(10)00545-X/fulltext
  7. https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(14)60601-7/fulltext

 

Lactobacillus Bulgaricus
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705123/
  2. https://www.ncbi.nlm.nih.gov/pubmed/21986509
  3. https://www.ncbi.nlm.nih.gov/pubmed/20487575
  4. https://www.ncbi.nlm.nih.gov/pubmed/22923109
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680912/
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475728/
  7. https://www.ncbi.nlm.nih.gov/pubmed/8432622
  8. https://www.ncbi.nlm.nih.gov/pubmed/10660098
  9. https://www.ncbi.nlm.nih.gov/pubmed/597607
  10. https://www.ncbi.nlm.nih.gov/pubmed/3564372

 

Lactobacillus Casei:
  1. https://www.ncbi.nlm.nih.gov/pubmed/26419583
  2. https://www.ncbi.nlm.nih.gov/pubmed/26689231
  3. https://www.ncbi.nlm.nih.gov/pubmed/24673738
  4. https://www.ncbi.nlm.nih.gov/pubmed/20838859
  5. https://www.ncbi.nlm.nih.gov/pubmed/21810608
  6. https://www.ncbi.nlm.nih.gov/pubmed/26672414
  7. https://www.ncbi.nlm.nih.gov/pubmed/22505595
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743185/
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744000/
  10. https://www.ncbi.nlm.nih.gov/pubmed/23992486
  11. https://www.ncbi.nlm.nih.gov/pubmed/21329565
  12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858332/
  13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160870/#B55

 

Lactobacillus Fermentum:
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670518/
  2. https://onlinelibrary.wiley.com/doi/abs/10.1002/jsfa.4214
  3. https://www.ncbi.nlm.nih.gov/pubmed/21218486
  4. https://www.sciencedirect.com/science/article/abs/pii/S0899900707000111?via%3Dihub
  5. https://www.ncbi.nlm.nih.gov/pubmed/27447674
  6. https://www.karger.com/Article/Abstract/328512
  7. https://bjsm.bmj.com/content/44/4/222

 

Lactobacillus Gasseri:

38. https://www.ncbi.nlm.nih.gov/pubmed/20216555

  1. https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effect-of-lactobacillus-gasseri-sbt2055-in-fermented-milk-on-abdominal-adiposity-in-adults-in-a-randomised-controlled-trial/304E3E2EE11E0D3D4F5D85E7046118A1
  2. Kadooka Y et al. Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomized controlled trial. Br J Nutr. 2013 Nov 14;110(9):1696-703.Epub 2013 Apr 25
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391304/
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611107/
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391304/
  6. Miyoshi M et al. Anti-obesity effect of Lactobacillus gasseri SBT2055 accompanied by inhibition of pro-inflammatory gene expression in the visceral adipose tissue in diet-induced obese mice.Eur J Nutr. 2014;53(2):599-606. doi: 10.1007/s00394-013-0568-9. Epub 2013 Aug 6.
  7. https://link.springer.com/article/10.1007%2Fs00203-015-1101-8
  8. https://www.wageningenacademic.com/doi/10.3920/BM2014.0108

 

Lactobacillus Plantarum:
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594053/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419998/
  3. https://www.researchgate.net/publication/304663353_Immunomodulatory_Effects_of_Lactobacillus_plantarum_Lp62_on_Intestinal_Epithelial_and_Mononuclear_Cells
  4. https://www.ncbi.nlm.nih.gov/pubmed/25598393
  5. https://www.ncbi.nlm.nih.gov/pubmed/26620542
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882673/
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936756/

 

Lactobacillus Reuteri:
  1. https://www.nature.com/articles/ejcn2012126
  2. https://www.ncbi.nlm.nih.gov/pubmed/22067612
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917019/
  4. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1348-0421.2009.00154.x
  5. https://www.ncbi.nlm.nih.gov/pubmed/25688886
  6. https://www.nature.com/articles/ejcn2012126
  7. https://www.ncbi.nlm.nih.gov/pubmed/25531996
  8. https://www.ncbi.nlm.nih.gov/pubmed/15629974
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813596/
  10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219330/
  11. https://www.omicsonline.org/open-access/beneficial-bacteria-stimulate-youthful-thyroid-gland-activity-2165-7904.1000220.php?aid=26919
  12. https://www.ncbi.nlm.nih.gov/pubmed/19895848

 

Lactobacillus Rhamnosus:
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155824/
  2. https://www.ncbi.nlm.nih.gov/pubmed/24299712
  1. https://www.ncbi.nlm.nih.gov/pubmed/26365389
  2. https://www.ncbi.nlm.nih.gov/pubmed/21899584
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844131/
  4. https://www.ncbi.nlm.nih.gov/pubmed/22692023
  5. https://www.ncbi.nlm.nih.gov/pubmed/22552453
  6. https://www.ncbi.nlm.nih.gov/pubmed/27596801
  7. https://www.ncbi.nlm.nih.gov/pubmed/23957340
  8. https://www.ncbi.nlm.nih.gov/pubmed/22702506
  9. https://www.ncbi.nlm.nih.gov/pubmed/26142892
  10. https://www.ncbi.nlm.nih.gov/pubmed/23740456

 

Bifidobacterium Breve:
  1. https://www.ncbi.nlm.nih.gov/pubmed/15491374
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1720633/
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048518/
  2. https://www.ncbi.nlm.nih.gov/pubmed/12598719
  3. https://www.ncbi.nlm.nih.gov/pubmed/16819382
  1. https://www.ncbi.nlm.nih.gov/pubmed/27590263
  2. https://www.ncbi.nlm.nih.gov/pubmed/15269618
  3. https://academic.oup.com/ajcn/article/93/1/81/4597712
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084046/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034291/
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965514/

 

Bifidobacterium Coagulans:
  1. https://www.ncbi.nlm.nih.gov/pubmed/25079465
  2. https://www.ncbi.nlm.nih.gov/pubmed/24271261
  3. https://www.ncbi.nlm.nih.gov/pubmed/2079358
  4. https://www.ncbi.nlm.nih.gov/pubmed/2086441
  5. https://www.ncbi.nlm.nih.gov/pubmed/23786900
  6. https://www.ncbi.nlm.nih.gov/pubmed/26430929
  7. https://www.ncbi.nlm.nih.gov/pubmed/24706266
  8. https://www.ncbi.nlm.nih.gov/pubmed/25196301
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826289/
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947834/
  2. https://www.ncbi.nlm.nih.gov/pubmed/25219857
  3. https://academic.oup.com/jn/article/145/7/1446/4589930
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784472/
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285933/
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443394/
  7. https://www.tandfonline.com/doi/full/10.1080/09168451.2014.972331
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724383/
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769834/
  10. https://www.ncbi.nlm.nih.gov/pubmed/20140275
  11. https://www.ncbi.nlm.nih.gov/pubmed/19332970
  12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129566/
  13. https://www.ncbi.nlm.nih.gov/pubmed/24867512
  14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460128/

 

Bifidobacterium infantis:
  1. https://www.nature.com/articles/pr2004591
  2. https://academic.oup.com/femspd/article/66/3/353/577227
  3. https://www.ncbi.nlm.nih.gov/pubmed/23192454
  1. https://www.ncbi.nlm.nih.gov/pubmed/20460726
  2. https://www.ncbi.nlm.nih.gov/pubmed/17189085
  3. https://gut.bmj.com/content/61/3/354
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744517/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744517/
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774839/
  4. https://jmm.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.47306-0#tab2
  5. https://www.ncbi.nlm.nih.gov/pubmed/17893165
  6. https://www.ncbi.nlm.nih.gov/pubmed/19291170
  7. https://academic.oup.com/femspd/article/55/3/324/496928
  8. https://www.ncbi.nlm.nih.gov/pubmed/17259812
  9. https://www.ncbi.nlm.nih.gov/pubmed/16689181
  10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997396/
  11. https://www.ncbi.nlm.nih.gov/pubmed/19367213
  12. https://www.ncbi.nlm.nih.gov/pubmed/16863564
  13. https://www.ncbi.nlm.nih.gov/pubmed/26418574
  14. https://www.ncbi.nlm.nih.gov/pubmed/25794930

 

Bifidobacterium Lactis (Note: was called “Bifidobacterium animalis in older studies”):
  1. https://www.sciencedirect.com/science/article/abs/pii/S089990071500461X?via%3Dihub
  2. https://www.nature.com/articles/pr2008218?proof=true&draft=journal
  3. https://www.ncbi.nlm.nih.gov/pubmed/18801055
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265429/
  5. https://www.ncbi.nlm.nih.gov/pubmed/16794305
  6. https://www.ncbi.nlm.nih.gov/pubmed/19236549
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171707/
  8. https://www.ncbi.nlm.nih.gov/pubmed/26268077
  9. https://www.ncbi.nlm.nih.gov/pubmed/19622191
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877827/
  2. https://www.ncbi.nlm.nih.gov/pubmed/15076628
  3. https://www.ncbi.nlm.nih.gov/pubmed/25599772
  4. https://www.ncbi.nlm.nih.gov/pubmed/15815206
  5. https://www.ncbi.nlm.nih.gov/pubmed/24322191
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761588/
  7. https://www.ncbi.nlm.nih.gov/pubmed/22284965
  8. https://www.ncbi.nlm.nih.gov/pubmed/17635382
  9. https://www.ncbi.nlm.nih.gov/pubmed/18801055

 

Bifidobacterium Longum:

151.https://www.ncbi.nlm.nih.gov/pubmed/15347767

  1. https://www.ncbi.nlm.nih.gov/pubmed/23192454
  2. https://academic.oup.com/femspd/article/66/3/353/577227
  3. https://www.ncbi.nlm.nih.gov/pubmed/22052061
  4. https://www.ncbi.nlm.nih.gov/pubmed/20460726
  5. https://jmm.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.47306-0
  6. https://www.ncbi.nlm.nih.gov/pubmed/19291170
  7. https://www.ncbi.nlm.nih.gov/pubmed/17259812
  8. https://www.ncbi.nlm.nih.gov/pubmed/24774670
  9. https://www.ncbi.nlm.nih.gov/pubmed/12906063
  10. https://www.ncbi.nlm.nih.gov/pubmed/16863564
  11. https://www.ncbi.nlm.nih.gov/pubmed/19367213

 

Saccharomyces Boulardii:
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296087/
  2. https://www.ncbi.nlm.nih.gov/pubmed/25653151
  3. https://www.ncbi.nlm.nih.gov/pubmed/15858959
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125647/
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829915/
  6. https://www.ncbi.nlm.nih.gov/pubmed/21997865
  7. https://www.ncbi.nlm.nih.gov/pubmed/18256417
  8. https://www.ncbi.nlm.nih.gov/pubmed/17306006
  9. https://www.ncbi.nlm.nih.gov/pubmed/27283364
  10. https://www.ncbi.nlm.nih.gov/pubmed/22476321
  11. https://www.ncbi.nlm.nih.gov/pubmed/22335323
  12. https://www.ncbi.nlm.nih.gov/pubmed/26216624
  13. https://www.ncbi.nlm.nih.gov/pubmed/7872284
  14. https://www.ncbi.nlm.nih.gov/pubmed/24311316
  15. https://www.ncbi.nlm.nih.gov/pubmed/15740542
  1. https://www.ncbi.nlm.nih.gov/pubmed/16572062
  2. https://www.ncbi.nlm.nih.gov/pubmed/15357564
  3. https://www.ncbi.nlm.nih.gov/pubmed/2494098
  4. https://www.ncbi.nlm.nih.gov/pubmed/7872284
  1. https://www.ncbi.nlm.nih.gov/pubmed/7872284

 

Streptococcus Thermophilus:
  1. https://www.ncbi.nlm.nih.gov/pubmed/14627358
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034325/
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526857/

 

Clinical Trial References for FEM PRO Formulation

At Doctors Pick, we only formulate nutritional products based on solid clinical evidence of potential benefits to you. Below is a list of the clinical trials, almost all on human participants, used as the basis for formulating FEM PRO.

References

Lactobacillus Acidophilus
1. https://www.cancer.gov/publications/dictionaries/cancer-drug/def/probiotic-acidophilus
2. https://www.ncbi.nlm.nih.gov/pubmed/8551535
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847857/
4. https://www.ncbi.nlm.nih.gov/pubmed/23747589
5. https://www.ncbi.nlm.nih.gov/pubmed/10067658
6. https://www.journalofdairyscience.org/article/S0022-0302(10)00545-X/fulltext
7. https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(14)60601-7/fulltext

Lactobacillus Bulgaricus
8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705123/
9. https://www.ncbi.nlm.nih.gov/pubmed/21986509
10. https://www.ncbi.nlm.nih.gov/pubmed/20487575
11. https://www.ncbi.nlm.nih.gov/pubmed/22923109
12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680912/
13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475728/
14. https://www.ncbi.nlm.nih.gov/pubmed/8432622
15. https://www.ncbi.nlm.nih.gov/pubmed/10660098
16. https://www.ncbi.nlm.nih.gov/pubmed/597607
17. https://www.ncbi.nlm.nih.gov/pubmed/3564372

Lactobacillus Casei:
18. https://www.ncbi.nlm.nih.gov/pubmed/26419583
19. https://www.ncbi.nlm.nih.gov/pubmed/26689231
20. https://www.ncbi.nlm.nih.gov/pubmed/24673738
21. https://www.ncbi.nlm.nih.gov/pubmed/20838859
22. https://www.ncbi.nlm.nih.gov/pubmed/21810608
23. https://www.ncbi.nlm.nih.gov/pubmed/26672414
24. https://www.ncbi.nlm.nih.gov/pubmed/22505595
25. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743185/
26. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744000/
26. https://www.ncbi.nlm.nih.gov/pubmed/23992486
28. https://www.ncbi.nlm.nih.gov/pubmed/21329565
29. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858332/
30. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160870/#B55

Lactobacillus Fermentum:
31. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670518/
32. https://onlinelibrary.wiley.com/doi/abs/10.1002/jsfa.4214
33. https://www.ncbi.nlm.nih.gov/pubmed/21218486
34. https://www.sciencedirect.com/science/article/abs/pii/S0899900707000111?via%3Dihub
35. https://www.ncbi.nlm.nih.gov/pubmed/27447674
36. https://www.karger.com/Article/Abstract/328512
37. https://bjsm.bmj.com/content/44/4/222

Lactobacillus Gasseri:
38. https://www.ncbi.nlm.nih.gov/pubmed/20216555
39. https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effect-of-lactobacillus-gasseri-sbt2055-in-fermented-milk-on-abdominal-adiposity-in-adults-in-a-randomised-controlled-trial/304E3E2EE11E0D3D4F5D85E7046118A1
40. Kadooka Y et al. Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomized controlled trial. Br J Nutr. 2013 Nov 14;110(9):1696-703.Epub 2013 Apr 25
41. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391304/
42. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611107/
43. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391304/
44. Miyoshi M et al. Anti-obesity effect of Lactobacillus gasseri SBT2055 accompanied by inhibition of pro-inflammatory gene expression in the visceral adipose tissue in diet-induced obese mice.Eur J Nutr. 2014;53(2):599-606. doi: 10.1007/s00394-013-0568-9. Epub 2013 Aug 6.
45. https://link.springer.com/article/10.1007%2Fs00203-015-1101-8
46. https://www.wageningenacademic.com/doi/10.3920/BM2014.0108

Lactobacillus Helveticus:
47. https://www.ncbi.nlm.nih.gov/pubmed/20974015
48. https://www.researchgate.net/publication/282244005_Administration_of_Lactobacillus_helveticus_NS8_improves_behavioral_cognitive_and_biochemical_aberrations_caused_by_chronic_restraint_stress

Lactobacillus Plantarum:
49. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594053/
50. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419998/
51. https://www.researchgate.net/publication/304663353_Immunomodulatory_Effects_of_Lactobacillus_plantarum_Lp62_on_Intestinal_Epithelial_and_Mononuclear_Cells
52. https://www.ncbi.nlm.nih.gov/pubmed/25598393
53. https://www.ncbi.nlm.nih.gov/pubmed/26620542
54. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882673/
55. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936756/

Lactobacillus Reuteri:
56. https://www.nature.com/articles/ejcn2012126
57. https://www.ncbi.nlm.nih.gov/pubmed/22067612
58. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917019/
59. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1348-0421.2009.00154.x
60. https://www.ncbi.nlm.nih.gov/pubmed/25688886
61. https://www.nature.com/articles/ejcn2012126
62. https://www.ncbi.nlm.nih.gov/pubmed/25531996
63. https://www.ncbi.nlm.nih.gov/pubmed/15629974
64. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813596/
65. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219330/
66. https://www.omicsonline.org/open-access/beneficial-bacteria-stimulate-youthful-thyroid-gland-activity-2165-7904.1000220.php?aid=26919
67. https://www.ncbi.nlm.nih.gov/pubmed/19895848

Lactobacillus Rhamnosus:
68. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155824/
69. https://www.ncbi.nlm.nih.gov/pubmed/24299712
70. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239510/
71. https://www.ncbi.nlm.nih.gov/pubmed/26365389
72. https://www.ncbi.nlm.nih.gov/pubmed/21899584
73. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844131/
74. https://www.ncbi.nlm.nih.gov/pubmed/22692023
75. https://www.ncbi.nlm.nih.gov/pubmed/22552453
76. https://www.ncbi.nlm.nih.gov/pubmed/27596801
77. https://www.ncbi.nlm.nih.gov/pubmed/23957340
78. https://www.ncbi.nlm.nih.gov/pubmed/22702506
79. https://www.ncbi.nlm.nih.gov/pubmed/26142892
80. https://www.ncbi.nlm.nih.gov/pubmed/23740456

Bifidobacterium bifidum:
81. https://www.ncbi.nlm.nih.gov/pubmed/27219886
82. https://www.ncbi.nlm.nih.gov/pubmed/27681077
83. https://www.ncbi.nlm.nih.gov/pubmed/28786012
84. https://www.ncbi.nlm.nih.gov/pubmed/28326881
85. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305430/
86. https://www.ncbi.nlm.nih.gov/pubmed/27209439
87. https://www.ncbi.nlm.nih.gov/pubmed/25604727
88. https://www.ncbi.nlm.nih.gov/pubmed/17878180
89. https://www.ncbi.nlm.nih.gov/pubmed/25909149
90. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133134/
91. https://www.ncbi.nlm.nih.gov/pubmed/22205338
92. https://www.ncbi.nlm.nih.gov/pubmed/25648808
93. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570661/
94. https://www.ncbi.nlm.nih.gov/pubmed/25244414
95. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630703/
96. https://www.ncbi.nlm.nih.gov/pubmed/15829425
97. https://www.ncbi.nlm.nih.gov/pubmed/27623957
98. https://www.ncbi.nlm.nih.gov/pubmed/1597660
99. https://www.ncbi.nlm.nih.gov/pubmed/21418261
100. https://www.ncbi.nlm.nih.gov/pubmed/18785988
101. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874795/

Bifidobacterium Breve:
102. https://www.ncbi.nlm.nih.gov/pubmed/15491374
103. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1720633/
104. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048518/
105. https://www.ncbi.nlm.nih.gov/pubmed/12598719
106. https://www.ncbi.nlm.nih.gov/pubmed/16819382
107. https://www.ncbi.nlm.nih.gov/pubmed/27590263
108. https://www.ncbi.nlm.nih.gov/pubmed/15269618
109. https://academic.oup.com/ajcn/article/93/1/81/4597712
110. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084046/
111. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034291/
112. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965514/

Bifidobacterium Coagulans:
113. https://www.ncbi.nlm.nih.gov/pubmed/25079465
114. https://www.ncbi.nlm.nih.gov/pubmed/24271261
115. https://www.ncbi.nlm.nih.gov/pubmed/2079358
116. https://www.ncbi.nlm.nih.gov/pubmed/2086441
117. https://www.ncbi.nlm.nih.gov/pubmed/23786900
118. https://www.ncbi.nlm.nih.gov/pubmed/26430929
119. https://www.ncbi.nlm.nih.gov/pubmed/24706266
120. https://www.ncbi.nlm.nih.gov/pubmed/25196301
121. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826289/
122. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947834/
123. https://www.ncbi.nlm.nih.gov/pubmed/25219857
124. https://academic.oup.com/jn/article/145/7/1446/4589930
125. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784472/
126. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285933/
127. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443394/
128. https://www.tandfonline.com/doi/full/10.1080/09168451.2014.972331
129. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724383/
130. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769834/
131. https://www.ncbi.nlm.nih.gov/pubmed/20140275
132. https://www.ncbi.nlm.nih.gov/pubmed/19332970
133. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129566/
134. https://www.ncbi.nlm.nih.gov/pubmed/24867512
135. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460128/

Bifidobacterium infantis:
136. https://www.nature.com/articles/pr2004591
137. https://academic.oup.com/femspd/article/66/3/353/577227
138. https://www.ncbi.nlm.nih.gov/pubmed/23192454
139. https://www.ncbi.nlm.nih.gov/pubmed/20460726
140. https://www.ncbi.nlm.nih.gov/pubmed/17189085
141. https://gut.bmj.com/content/61/3/354
142. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744517/
143. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744517/
144. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774839/
145. https://jmm.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.47306-0#tab2
146. https://www.ncbi.nlm.nih.gov/pubmed/17893165
147. https://www.ncbi.nlm.nih.gov/pubmed/19291170
148. https://academic.oup.com/femspd/article/55/3/324/496928
149. https://www.ncbi.nlm.nih.gov/pubmed/17259812
150. https://www.ncbi.nlm.nih.gov/pubmed/16689181
151. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997396/
152. https://www.ncbi.nlm.nih.gov/pubmed/19367213
153. https://www.ncbi.nlm.nih.gov/pubmed/16863564
154. https://www.ncbi.nlm.nih.gov/pubmed/26418574
155. https://www.ncbi.nlm.nih.gov/pubmed/25794930

Bifidobacterium Lactis (Note: was called “Bifidobacterium animalis in older studies”):
156. https://www.sciencedirect.com/science/article/abs/pii/S089990071500461X?via%3Dihub
157. https://www.nature.com/articles/pr2008218?proof=true&draft=journal
158. https://www.ncbi.nlm.nih.gov/pubmed/18801055
159. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265429/
160. https://www.ncbi.nlm.nih.gov/pubmed/16794305
161. https://www.ncbi.nlm.nih.gov/pubmed/19236549
162. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171707/
163. https://www.ncbi.nlm.nih.gov/pubmed/26268077
164. https://www.ncbi.nlm.nih.gov/pubmed/19622191
165. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877827/
166. https://www.ncbi.nlm.nih.gov/pubmed/15076628
167. https://www.ncbi.nlm.nih.gov/pubmed/25599772
168. https://www.ncbi.nlm.nih.gov/pubmed/15815206
169. https://www.ncbi.nlm.nih.gov/pubmed/24322191
170. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761588/
171. https://www.ncbi.nlm.nih.gov/pubmed/22284965
172. https://www.ncbi.nlm.nih.gov/pubmed/17635382
173. https://www.ncbi.nlm.nih.gov/pubmed/18801055

Bifidobacterium Longum:
174. https://www.ncbi.nlm.nih.gov/pubmed/15347767
175. https://www.ncbi.nlm.nih.gov/pubmed/23192454
176. https://academic.oup.com/femspd/article/66/3/353/577227
177. https://www.ncbi.nlm.nih.gov/pubmed/22052061
178. https://www.ncbi.nlm.nih.gov/pubmed/20460726
178. https://jmm.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.47306-0
180. https://www.ncbi.nlm.nih.gov/pubmed/19291170
181. https://www.ncbi.nlm.nih.gov/pubmed/17259812
182. https://www.ncbi.nlm.nih.gov/pubmed/24774670
183. https://www.ncbi.nlm.nih.gov/pubmed/12906063
184. https://www.ncbi.nlm.nih.gov/pubmed/16863564
185. https://www.ncbi.nlm.nih.gov/pubmed/19367213

Bacillus Subtilis:
186. https://www.ncbi.nlm.nih.gov/pubmed/23328284
187. https://www.microbiologyresearch.org/content/journal/jmmcr/10.1099/jmmcr.0.004036
188. DOI: https://doi.org/10.1016/j.celrep.2019.12.078

Saccharomyces Boulardii:
189. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296087/
190. https://www.ncbi.nlm.nih.gov/pubmed/25653151
191. https://www.ncbi.nlm.nih.gov/pubmed/15858959
192. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125647/
193. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829915/
194. https://www.ncbi.nlm.nih.gov/pubmed/21997865
195. https://www.ncbi.nlm.nih.gov/pubmed/18256417
196. https://www.ncbi.nlm.nih.gov/pubmed/17306006
197. https://www.ncbi.nlm.nih.gov/pubmed/27283364
198. https://www.ncbi.nlm.nih.gov/pubmed/22476321
199. https://www.ncbi.nlm.nih.gov/pubmed/22335323
200. https://www.ncbi.nlm.nih.gov/pubmed/26216624
201. https://www.ncbi.nlm.nih.gov/pubmed/7872284
202. https://www.ncbi.nlm.nih.gov/pubmed/24311316
203. https://www.ncbi.nlm.nih.gov/pubmed/15740542
204. https://www.ncbi.nlm.nih.gov/pubmed/16572062
205. https://www.ncbi.nlm.nih.gov/pubmed/15357564
206. https://www.ncbi.nlm.nih.gov/pubmed/2494098
207. https://www.ncbi.nlm.nih.gov/pubmed/7872284
208. https://www.frontiersin.org/articles/10.3389/fnagi.2016.00256/full

Saffron:
209: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599112/
210: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643654/
211. https://www.ncbi.nlm.nih.gov/pubmed/27595298
212. https://www.ncbi.nlm.nih.gov/pubmed/15707766
213. https://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/j.1471-0528.2007.01652.x
214. https://www.ncbi.nlm.nih.gov/pubmed/19720342
215. https://www.ncbi.nlm.nih.gov/pubmed/20831681
216. https://www.ncbi.nlm.nih.gov/pubmed/19838862
217. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941716/
218. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850693/
219. https://www.ncbi.nlm.nih.gov/pubmed/20688744
220. https://www.ncbi.nlm.nih.gov/pubmed/30343354

Inubio™ Prebiotic Ingredients—Inulin, Chicory Root & Jerusalem Artichoke:
221. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686634/
222. https://www.ncbi.nlm.nih.gov/pubmed/28596023?dopt=Abstract
223. ttps://academic.oup.com/jn/search-results?f_TocHeadingTitle=Inulin%20and%20Oligofructose:%20Health%20Benefits%20and%20Claims-A%20Critical%20Review
224. https://academic.oup.com/jn/article/137/11/2524S/4664499
225. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705355/
226. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896694/
227. https://www.ncbi.nlm.nih.gov/pubmed/24688953
228. https://www.ncbi.nlm.nih.gov/pubmed/18853230
229. https://www.ncbi.nlm.nih.gov/pubmed/27623982
230. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041804/